Epsilon aminocaproic acid (EACA) is the generic form of Amicar™ that is recommended for all retired racing greyhounds for five days (one day pre-operative, operative day, and three days post-operative) with any surgical procedure to prevent the post-operative bleeding that is common in greyhounds. Lilian Marin, et al concluded that administration of EACA significantly decreased the prevalence of delayed post-operative bleeding in retired racing greyhounds undergoing surgery by amplifying/strengthening of the fibrin clot.
EACA in pill or capsule form in the U.S. has increasingly become difficult to obtain or overly expensive leading to greyhounds undergoing procedures without this useful agent. The Greyhound Health Initiative suggests using Aminocaproic acid Injection formula given orally at the same dosage; this appears to be as effective as pill/capsule form. The injection formula can be purchased from Covetrus (FKA Henry Schein Animal Health) or other animal health retailers at a very reasonable price. The veterinarian can provide syringes with the appropriate volume to the owner and they simply give the liquid orally every eight hours for five days. We do not currently have scientific data or publications supporting this approach but it appears to be effective in preventing post-operative bleeding and has been used extensively in many areas of the U.S.
This post-operative bleeding disorder is not commonly seen in other sighthounds breeds, except for deerhounds. The Greyhound Health Initiative does not currently recommend using Amicar for other sighthound breeds but cautions veterinarians to have it on hand when doing procedures on any sighthound.
An alternative to EACA is Tranexamic Acid (TXA) which is readily available in the U.K. and Canada and is recommended for use to decrease post-operative bleeding in greyhounds when EACA is not available in pill or liquid form. TXA can be given intravenously or in pill form for oral administration. The above method of giving the liquid form orally has not been evaluated, so we cannot recommend it at this time.
EACA in liquid or pill formulation: 500 to 1,000mg three times a day (every eight hours) for five days. Recommend starting this regimen one day before the procedure if possible.
TXA: 7mg/kg to 10mg/kg, IV* three times a day for five days or the capsule formulation use 5mg/kg to 10mg/kg orally three times a day for five days.
*IV TXA can cause immediate vomiting when given at the high-end of the dose range